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SUBIECT: Geron - test clinic cu celule stem embrionare, SUA

Rasp: Re:Geron - test clinic cu celule stem embrionare #25114

First test of human embryonic stem cell therapy in people discontinued

By Rob Stein, Published: November 15

The company conducting the first government-approved tests in people of a therapy developed using human embryonic stem cells abruptly announced Monday that it was halting the study, stunning advocates of the highly contentious field.

Geron Corp. of Menlo Park, Calif., said the move, which stops one of the most controversial and closely watched medical experiments in the history of biomedical research, was the result of a business decision to focus exclusively on developing cancer therapies.

“In the current environment of capital scarcity and uncertain economic conditions, we intend to focus our resources on advancing our . . . two novel and promising oncology drug candidates,” John A. Scarlett, Geron’s chief executive officer, said in a statement. “This would not be possible if we continue to fund the stem cell programs at the current levels.”

The company also announced that it was eliminating 66 full-time positions, representing 38 percent of its workforce.

Another company continues to test a second embryonic stem cell therapy in people. But Geron’s announcement marked a major setback and disappointment, researchers and advocates said.

“While stem cells are proving invaluable for research, translating the promising science into new therapies is a slow, painstaking process with many setbacks,” said George Q. Daley, a leading stem cell researcher at Harvard Medical School. “A safe first trial would have paved the way for many others to follow.”

The announcement Monday was a particular blow to advocates of research into spinal cord injuries and patients suffering from paralysis. The study was testing the treatment on partially paralyzed patients.

“I’m disgusted. It makes me sick,” said Daniel Heumann, who is on the board of the Christopher and Dana Reeve Foundation. “To get people’s hopes up and then do this for financial reasons is despicable. They’re treating us like lab rats.”

Human embryonic stem cell research has been the focus of intense excitement and acrimonious public debate, but it has so far shown promise only in animal and laboratory studies. The Geron study was the first government-sanctioned attempt to test a therapy using the cells in people.

Although the company will not treat any additional patients, researchers will continue to follow the four patients treated so far, “accruing data and updating FDA and the medical community on their progress,” Geron said. The company is also “seeking partners with the technical and financial resources to enable further development” of its stem cell therapy, it said.

Many scientists think embryonic stem cells could represent one of the most important advances in medicine. Because the cells can morph into virtually any cell or tissue, researchers hope they will eventually produce cures for a host of ailments, including heart disease, cancer, Alzheimer’s and paralysis.

But the field is fraught with political, moral and ethical controversies. Days-old embryos have been destroyed to obtain the cells, which critics consider immoral. After many delays, the Food and Drug Administration last year approved two experiments testing therapies created from embryonic stem cells in humans, including a study testing Geron’s experimental treatment on 10 patients partially paralyzed by spinal cord injuries. Both studies were designed primarily to determine whether the approach is safe.

https://www.washingtonpost.com/national/health-science/first-test-of-human-embryonic-stem-cell-therapy-in-people-discontinued/2011/11/14/gIQAQBTOMN_story.html?tid=pm_national_pop
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Rasp: Re:Geron - test clinic cu celule stem embrionare #25207

Stanford team treats final patient in landmark stem cell therapy trial

The Stanford University School of Medicine and Santa Clara Valley Medical Center treated the fifth patient in the Geron Corp-sponsored trial of a human embryonic-stem-cell-derived treatment for severe spinal cord injury on Nov. 16.

https://medicalxpress.com/news/2011-11-stanford-team-patient-landmark-stem.html
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Rasp: Re:Geron - test clinic cu celule stem embrionare #25951

Nu am avut timp sa urmaresc noutatile si sa vad ce s-a intamplat. Urmareste cineva stirile din domeniul cercetarii pe siteurile straine?
Ce parere aveti despre faptul ca Geron a oprit testele clinice? Un test clinic, care fusese atat de mult asteptat, e oprit doar dupa cativa pacienti.
Sper sa am timp, sa vad ce s-a intamplat.
Voi stiti ceva?
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Rasp: Re:Geron - test clinic cu celule stem embrionare #25955

Poate nu este oprit ci pur si simplu nu este inca nimic ce-ar putea fi dat publicitatii in sensul ca inca nu sunt rezultate cu care sa poata iesi in fata! In esenta, astfel de cercetari sunt destul de anevoioase! Multa sanatate si... Doamne-ajuta!
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Tot ce vreti sa va faca voua oamenii, faceti-le si voi la fel...Matei 7:12
Doamne...ajuta-ma ca azi, sa fiu mai aproape de Tine decat ieri si maine (daca mai e o zi pentru mine) mai aproape decat azi! AMIN!
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Rasp: Re:Geron - test clinic cu celule stem embrionare #25965

Testul clinic a fost oprit. Din articol, Geron spune ca l-a oprit din cauza conditiilor economice nesigure - adica a crizei. Vor sa se axeze mai mult pe cercetarea in domeniul cancerului.
Ei au cheltuit deja o gramada de bani ca sa porneasca acest test. Acuma ...ori nu mai au bani sa continue, ori cred ca nu vor avea rezultate, ori nu vor avea destul profit in caz ca functioneaza; nu stiu, dar testul a fost oprit, dupa cativa pacienti.
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Următorii utilizatori v-au mulțumit: daniel

Rasp: Geron - test clinic cu celule stem embrionare #25994

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